Parasitic For Malaria Drug Resistance
One of the technical difficulties for malaria prevention is the emergence of resistant parasites. Now when it comes to drug resistance, it is mainly about the phenomenon of Plasmodium falciparum resistant to asexual drugs. But there have been also chlorinated plasmodium vivax in Indonesia, Papua New Guines and Solomon Islands in 1991 and 1992.
Definition of drug resistance of malaria parasites
Drug resistance is defined as the ability of a parasite (or strain) to survive and thrive even though a patient has been treated and absorbed a quantity of malaria drug. This medicine is given in doses equal to or higher than the usual dose but within the body's tolerance
Favorable factors for drug resistance of the malaria parasite
Drug pressures: Under natural conditions, there is a small percentage of resistant parasites in the malaria parasite population.
Under the pressure of the drug (due to treatment, prophylaxis) the sensitive parasites will be destroyed, leaving the parasite resistant to that drug. These parasites will develop and cause resistance
Citizens' immunity: In a somewhat immunized population (having suffered from malaria many times, living for years in severely endemic malaria areas), one dose of the drug could kill low-resistance strains ( and patients recover, do not spread the disease), while in people who do not have immunity or weak immunity, the drug will fail, it will not cure the disease and these resistant strains will spread throughout the area. field.
Transmission vector: field and in-field observations show that Anopheles spp mosquito, which is resistant to resistant strains, as this parasite grows faster than susceptible strains in mosquitoes.
Population fluctuations: Shown in the malaria area, the receptors are not immune. If malaria increases, the population of parasites and resistant strains will be included. On the other hand, the gamete of the drug-resistant parasite is introduced to the area without resistance, causing the emergence and spreading of the resistance here.
The half-life of malaria drugs: If the antimalarial drug has a long half-life, there will be a segment of drug present in the blood with insufficient concentrations to kill the parasite
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