Psoriasis And Its Etiology

Psoriasis is a common skin disease, accounting for about 1.5-2% of the population. This disease is hereditary.
Inherited by many genes. If only one parent has psoriasis, then 8.1% of the children will be infected, if both parents have the disease, 41% will be sick.
Causes: psoriasis is thought to be caused by immunity, specifically activated T lymphocytes, secreting mediators that cause disease.
Onset of illness at all ages, from birth (psoriasis diaper) to 108 years old but most are 20-30 years old


Meet in both sects equally
Race: also involved in determining pathogenicity. Japanese, West Indies and Eskimo have low incidence of infection.


Psoriasis And Its Etiology

. North and South American Indians have virtually no illnesses or very low frequency.
Several factors involved in the disease: psychological trauma, physical trauma, infection, medication.
The cause to the illness
The pathogenesis of psoriasis today is more clearly understood. In which immunity plays a key role, there are a number of other factors involved.
Immune factor
It is now thought that the cause is caused by immunotherapy: activated T lymphocytes release cytokines
These cytokines cause skin cells to reproduce, grow quickly and increase in numbers more than usual Biological treatment is to prevent the activation of T lymphocytes.
Genetic factors
Has been clearly identified, encountered in 30-40% of psoriasis. People with psoriasis usually have the appropriate antigen organization: HLA-B13, HLA-B17, HLA-B27, HLA-Bw57 and HLA-Cw6.
Mental factor
Psychological trauma may trigger the disease, causing it to recur or make it worse.


Psoriasis And Its Etiology

.
Biochemical factor
There are metabolic abnormalities of arachidonique acid, changes in the number of cyclic nucleotides.
Due to the drug
Some medications can cause psoriasis: beta-bloquants, lithium, synthetic anti-malarial, some nonsteroidal anti-inflammatory drugs.
Other causes
Bacteria (streptococcus), super bacteria, etc. are also involved
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