Psoriasis And Its Etiology
Psoriasis is a common skin disease, accounting for about 1.5-2% of the population. This disease is hereditary.
Inherited by many genes. If only one parent has psoriasis, then 8.1% of the children will be infected, if both parents have the disease, 41% will be sick.
Causes: psoriasis is thought to be caused by immunity, specifically activated T lymphocytes, secreting mediators that cause disease.
Onset of illness at all ages, from birth (psoriasis diaper) to 108 years old but most are 20-30 years old
Meet in both sects equally
Race: also involved in determining pathogenicity. Japanese, West Indies and Eskimo have low incidence of infection.
. North and South American Indians have virtually no illnesses or very low frequency.
Several factors involved in the disease: psychological trauma, physical trauma, infection, medication.
The cause to the illness
The pathogenesis of psoriasis today is more clearly understood. In which immunity plays a key role, there are a number of other factors involved.
It is now thought that the cause is caused by immunotherapy: activated T lymphocytes release cytokines
Has been clearly identified, encountered in 30-40% of psoriasis. People with psoriasis usually have the appropriate antigen organization: HLA-B13, HLA-B17, HLA-B27, HLA-Bw57 and HLA-Cw6.
Psychological trauma may trigger the disease, causing it to recur or make it worse.
There are metabolic abnormalities of arachidonique acid, changes in the number of cyclic nucleotides.
Due to the drug
Some medications can cause psoriasis: beta-bloquants, lithium, synthetic anti-malarial, some nonsteroidal anti-inflammatory drugs.
Bacteria (streptococcus), super bacteria, etc. are also involved
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