Parkinson’s Disease In The Elderly

Parkinson's disease, also known as fibrillation disease, is a disease caused by deterioration of the nervous system. It is common in people older than 50 and the majority of men, with the incidence of 1/500. People with Parkinson's disease often have many difficulties in daily life and can lead to depression.
Reason
Currently, the cause of Parkinson's disease is still unknown, but found that in patients with dopamine, the content of dopamine in the body is significantly reduced! Dopamine is a neurotransmitter belonging to the catecholamine group (including: dopamine, noradrenalin, adrenalin) concentrated in the basal ganglia of the brain. Dopamine plays an important role in the movement and coordination of body movements

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When dopamine-producing cells degenerate or die, dopamine deficiency in the body is a risk factor for parkinson's disease.

There are also some favorable factors such as:
- Often exposed to pesticides, herbicides.
- History of head injury, encephalitis

- Atherosclerosis .



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Symptom
The symptoms of Parkinson's disease usually progress in a long time:
- At first tremor in one hand, then spread to the legs on the same side and gradually tremble on both sides.
- Patients often have stiff postures, sluggish, expressionless faces, stooping gait forward, or imbalance.
- Patients have difficulty writing letters, anxiety often leads to depression.
Treatment
Currently, medicine has not been able to cure Parkinson's disease but helps prevent the development of the disease through the following methods:
- Physical therapy method: In the early stages of Parkinson's disease, the application of physiotherapy helps to significantly improve the ability of movement and mental support for patients.
- Method of medication: Levodopa: this is the main medicine used to treat Parkinson's and RLS The use of levodopa will help patients reduce symptoms and improve the quality of life.




Levodopa is a precursor of dopamine. Once in the body, levodopa crosses the blood-brain barrier and specialized in hopopamine (dopamine does not cross the blood-brain barrier so cannot be used directly).
However, in the periphery, levodopa is converted to dopamine by decarboxylase enzymes, so levodopa is often combined with these enzyme inhibitors such as carbidopa, benserazid with preparations such as sinemet (levodopa + carbidopa), madopar (levodopa + benserazid). To increase the effectiveness of treatment, levodopa is often used in combination with the following drugs: -Amantadine is a treatment for the influenza virus type A2 but is also used in the treatment of Parkinson's disease. Amantadine helps stimulate the release of endogenous dopamine.
-Dopamine agonists (dopamine agonists) include bromocriptin, pergolid, pramipexole ...



stimulating directly on dopaminergic receptors.
-Cholin secreting drugs: including trihexyphenidyl, benzatrophine, procyclidine ... Currently these drugs are rarely used in the treatment of Parkinson's disease.
Surgical method Surgical method is used when the above methods do not bring the desired treatment effect. Brain surgery will significantly improve the symptoms of tremor, rigidity ..



. of people with Parkinson's disease..

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