Some Drugs Are Nephrotoxic
The kidneys are the main organ for drug elimination. Renal parenchyma is very sensitive to the drug. The drug can cause renal damage according to the mechanisms: reduced renal perfusion, direct toxic to renal tubular cells, interstitial damage, renal vascular occlusion, tubular obstruction and manifestations of acute and renal failure. side.
If you use multiple drugs at the same time and have drug interactions, the risk of unwanted drug reactions 3 times
- Antibiotics:
+ Betalactam group: penicillin and cephalosporin can cause anaphylactic shock and acute renal failure.
+ Aminoglucosid group (gentamycin, amikacin, tobramycin .
) directly toxic to renal tubular cells.+ Tuberculosis resistant group (rifamycin ...).
+ Antifungal group (amphotericin B).
- Nonsteroidal anti-inflammatory drugs (indometacin, analgin, phenylbutazon, paracetamol
.) can cause acute hepatitis and acute renal tubular necrosis. Long-term use can cause chronic interstitial nephritis.- ACE inhibitors (captopril, quinapril, enalapril, lisinopril ...) cause decreased renal perfusion and acute renal failure. Do not appoint ACE inhibitors in hypertension due to renal artery stenosis.
- AT1 receptor antagonists (irbesartan, valsartan, losartan, telmisartan) may cause acute renal failure.
- Medications for treating blood fats (fibrates, statins) may affect kidney function.
- Treatment of gout (allopurinol, colchicin).
- Immunosuppressant drugs (cyclosporin, tacrolimus ...).
- Anticancer drugs (cisplatin, methotrexate, cyclophosphamide).
- Contrast with iodine can cause anaphylactic shock and obstruction of renal blood vessels.
- Diuretics (thiazide, furosemid ...) may cause functional acute renal failure.
- A number of traditional medicine and traditional medicines.
To prevent drug-induced kidney complications, we should follow the following principles: Prescribe the right medication for the right person, for the right person.
Note the elderly, pregnant people, small children with weight, dehydration status to specify the dose.
Limit the use of many drugs and avoid drug interactions.If taking the drug for a long time should be monitored renal function, liver function. If you already have kidney disease, take the medication very carefully in the indications and should be carefully monitored.. . Dịch vụ: Thiết kế website, quảng cáo google, đăng ký website bộ công thương uy tín
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