Note When Using Anti-nausea Drug Domperidon

Domperidone is a dopamine receptor antagonist with antiemetic properties similar to metoclopramide and other psychotropic drugs. The drug is indicated for widespread use with cases of gastrointestinal dysfunction, especially nausea and vomiting due to many causes.
Because of this, many people abuse drugs, especially children, leading to poisoning and dangerous events such as: heart disorders, meningeal damage, gastrointestinal bleeding ..

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Domperidon is indicated in which case?
Indigestion symptoms that are often associated with delayed gastric emptying, gastroesophageal reflux and esophagitis: feeling of fullness, fullness, tightness in the abdomen, upper abdominal pain; Bloating, flatulence, belching; Burns behind the sternum with or without burp of stomach contents to mouth.
Nausea and vomiting are caused by various causes, especially effective for nausea and vomiting caused by dopamine agonists in patients with Parkinson's disease (such as L-dopa and bromocriptin).
Domperidone drug is indicated in cases of dyspepsia, nausea, etc
Sugar administration and the potential for catastrophic events
Oral administration: This is the most common and safest route of use, however, its effectiveness is limited.



Domperidone is absorbed from the intestinal tract, is rapidly changed in the intestine and liver so its bioavailability is low.
If you want it to be effective, you should take it 15 - 30 minutes before meals, with a sufficiently high dose and then every 4-8 hours orally once.
Use intravenously: Effective quickly, but most likely to cause complications is the ability to cause torsades de pointes.
Special intravenous route should not be used for people with arrhythmia or hypokalemia, who are undergoing chemotherapy for cancer. Currently, many countries have banned the use of domperidone by this route.
Intramuscular use: Domperidon is effective as oral route, but only used when absolutely necessary (when patients can not drink) because it is easy to cause complications such as intravenous injection.
Things to keep in mind when using the drug
Domperidone is a drug that increases intestinal motility If used improperly dose easily cause gastrointestinal disorders.



If used for people with mechanical intestinal obstruction, bleeding from the gastrointestinal tract, there will be catastrophic events, especially for children.
Domperidon is on the list of drugs capable of causing torsades de pointes. In the case of severe diarrhea, excessive vomiting will cause loss of salt - water, with low blood potassium, the ability to cause torsades de pointes more easily revealed.
Domperidone can be used for people with Parkinson's but only in the absence of other safer antiemetic measures and should not be used for more than 12 weeks. For women, domperidone increases prolactin secretion, which causes milk leakage, breast tenderness, and breast enlargement, causing menstrual disorders.
Although domperidone has no evidence of teratogenicity, there is no complete information on the safety of the fetus, so it should not be used for pregnant and lactating women. Although the drug does not cause birth defects, it can cause rapid ventricular tachycardia, which is dangerous to the life of the mother.
Pregnant women should not use antiemetics because they can cause unfortunate side effects
For children under 1 year of age: Because the metabolic function and blood brain barrier function are not fully developed, the ability to penetrate the blood brain barrier of the drug is not completely excluded, so it requires professional advice.



before use
For children older than 1 year: Children with vomiting for many reasons, sometimes do not need to use drugs or can choose to use other drugs that are still effective, less toxic. Only use domperidone when absolutely necessary (as indicated and when there is no better alternative medicine). Suitable form for children is suppositories, granular form, effervescent (pack 10mg), oral suspension (5mg / 5ml).
It is necessary to strictly follow the directions on the dose and duration of use, it is best to consult medical staff before use.
Unwanted effects
Few cases of transient intestinal spasm have been reported. Extrapyramidal phenomenon is rare in children and not seen in adults. If so, this phenomenon will recover completely and quickly immediately after stopping the drug.
Symptoms of overdose include drowsiness, disorientation and extrapyramidal reactions, especially in children.




Manifestations appear after drinking from 30 minutes to 6 hours: arching, stiffness, convulsions, tongue sticking, crooked neck, eyes looking up, abnormal eye rotation ... easily vulnerable to encephalitis - meningitis , brain hemorrhage. In newborns, the drug also causes cyanosis, drowsiness, abortion, breathing disorders, very dangerous.
In case of overdose, it is necessary for patients to take activated charcoal and taken immediately to the nearest medical facility for treatment and monitoring..

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