Papaverin: How To Use It Safely?

Today, papaverin's designation differs from before. If you do not know this information, the use of medication will not be effective and may cause a catastrophe.

Papaverin is an active ingredient extracted from opium poppy, but only has anti-spasmodic effect, so it reduces pain of spasms without inhibiting the central nervous system like other opioid active substances (morphine, codeine).

The mechanism of papaverin's antispasmodic action is to inhibit phosphorylation and interfere with muscle contraction. Spread out, it also destroys spasms caused by acetylcholine, bradykinin, serotonin

. Papaverin is listed as an anti-spasmodic analgesic. Used as a pain reliever due to increased gastrointestinal motility (in colitis, gastroenteritis, inflammation of the intestine) due to uterine contractions (in menstrual system) due to renal or biliary colic (in nephritis, gallbladder).

Papaverin also prevents cerebral vasospasm, peripheral, relax myocardium, used to be used in cerebral ischemia, myocardial ischemia, bronchospasm due to asthma, angina pectoris

However, it did not bring certain effects.



Now there are many alternatives to treat these diseases that are better, less toxic, so they are not used anymore.

There is not enough information about the harm of papaverin to pregnancy, and the reproductive process. In the past, it was used to fight against "threatened to miscarry", now because there are better, safer drugs, it is rarely used. The latest documents (such as Vietnam Pharmacopoeia 2002) read 'Do not use papaverin for pregnant women'. There are no adequate information on the excretion of papaverin into milk, avoiding its use for nursing mothers.

Papaverin may cause hypersensitivity phenomena. Hypersensitivity in the liver manifests jaundice, digestive disorders, eosinophilia, changes in liver enzymes

Not recommended for people with a history of hypersensitivity to this drug.



Immediately stop the drug when there is a phenomenon of liver hypersensitivity.

Papaverin intravenous drug when injected quickly can cause arrhythmia, apnea, death. Extreme caution should be exercised when taking this form of medication. Do not mix papaverin injected into Ringer lactate infusion because it causes precipitation, drug degradation, leading to catastrophe.

Papaverin may also cause atrial-ventricular conduction loss, transient ventricular premature beats, premature beats, or paroxysmal tachycardia. Do not use it when you have atrioventricular block completely and with extreme caution. Atrioventricular conduction loss. Do not use for people with parkinson's disease, especially when taking levodopa medication because it will cause adverse interactions.



Papaverin vasoconstrictor, hypertension, should not be used for people with cranial hypertension, glaucoma.

Although the drug is very neurological, but if used in high doses and (or) can cause dizziness, headache, drowsiness, lethargy and familiarity.
When taking papaverin appears effective very quickly, sustained for about 6 hours, so should be taken every 6 hours. If the oral form of the active ingredient is released slowly, the effect appears later but is maintained for 12 hours, so the effective dose should be taken every 12 hours apart.

In the List of medicines mainly used in medical examination and treatment facilities (March 2005, QD-BYT), the oral papaverin (40mg tablets) and injections (40mg / ml) are listed in the antispasmodics section (XVIII- 6) and oral papaverin (40 mg) are still listed in the anti-preterm section (XXIII-2), are allowed for use in lines 1 + 2, 3 and other facilities with a doctor.

Need to use according to the specified route. Care should be taken, there is still a foreign papaverin (capsule dissolved in the intestine, 100mg) that shows the old indications (on the brain, heart, memory impairment of the elderly) with a higher instruction dose (400-600mg / day).

DS.



Hanh Lam Lake.

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