Effects Of Drugs On Hearing

Everyone knows that the drug is a double-edged sword, besides healing effects, it has side effects or undesirable effects. Scientists have shown that there are drugs that are very toxic to hearing cells.
Antibiotics aminoglycosides (gentamicine, nomomine, amikacine ..

.). Be cautious because this antibiotic poisoning is not only seen when systemic (injectable, infusion) is administered, but can also occur when localized (drops into the ear when the eardrum is leaking). Some ear drops contain this antibiotic
Some diuretics such as furosémide, acide étacrynique .



.. Cisplatine line cancer drugs. Quinine derivatives, acetylsalicylique acide.
How does medicine affect hearing?
When absorbed into the ear in these drugs will destroy hearing cells leading to deafness, also known as ear poisoning phenomenon (ear poisoning). The degree of damage to the inner ear depends on the medicine, the dose, the duration of use and depends on the individual's reaction to the medication.
The risk of deafness from drug intoxication may appear as soon as the medication is started starting until treatment is stopped for about 2 to 6 weeks Initially the patient often tinnitus and feeling dizzy then later hearing loss.




Some cases of patients with hearing loss simultaneously with tinnitus. Patients often complain of tinnitus in the ears with high pitches such as cicadas, whistling winds ... The feeling of dizziness sometimes does not appear or only slight lightheadedness but there are cases of intense vertigo.

Hearing loss is also in varying degrees, sometimes the patient feels tinnitus only but does not feel bad, especially in cases of both deaf and white deafness. This poisoning usually occurs in both ears proportionally, but in case of poisoning by ear drops, hearing damage only occurs on the side with the drops.
Ear-nose-throat examination usually does not detect damage to the outer ear, eardrum and middle ear.



Only when measuring audiometry alone can we see that the hearing threshold is reduced, mainly in the high frequency area (8000 Hz), the bias of the two-ear proportion. In young children, drug-induced inner ear toxicity is often detected late. Hearing loss greatly affects a child's language development.

What to do to limit the harmful effects of drugs on hearing?
Understanding the harmful effects of drugs, pharmaceutical companies around the world are always trying to find derivatives or alternative drugs with fewer side effects. In fact, doctors always consider the benefits and benefits of each medication on a case-by-case basis, but sometimes still have to accept it for the safety of their patients.
On the patient's side, you should be more cautious when taking medications that are not prescribed by a doctor. Every year, Hopital Hospital has had to receive many cases of internal deafness due to ear drops that are not prescribed.

There are many ear drops that contain aminoside antibiotics (such as polidexa, néodexa, etc.



) on the market. These medications should be used only in cases of inflammation of the outer ear canal and closed eardrum. They are forbidden to use when the eardrum is punctured because the drug passes through the hole into the middle ear and directly affects the hearing cells in the inner ear. Hearing loss due to ear drops poisoning can occur soon after dosing, but some tinnitus and hearing loss appear after a few weeks of stopping the drops.

Treatment of drug-induced ototoxicity
The damage that toxins to the inner ear cause to hearing cells is unlikely to recover. Until now, the treatment of deafness caused by drug poisoning is still a difficult question for medicine. When the symptoms of intoxication with the inner ear appear, tell the doctor. Your doctor will weigh the pros and cons to decide whether to continue the treatment or whether to stop.



But stopping this treatment does not guarantee that the inner ear poisoning process will stop or continue for some time (possibly up to 6 weeks after stopping the drug).

There is currently no medicine that is effective at treating drug-induced ototoxicity. If hearing loss is severe, affecting communication, hearing aids should be used. Hearing aids not only assist hearing but also help reduce tinnitus. Some cases of severe and deep deafness in both ears that hearing aids do not work are another solution is cochlear electrode implant surgery. But surgery is very expensive and after surgery to understand the words patients have to follow special training, lasting for years. Because of this sophisticated treatment, high cost and long lasting, not all patients can afford it..

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