Hepatitis B Antibody, Treats When Exposed To The Hepatitis B Virus

Hepatitis B surface antibody (HBsAb or anti-HBs) is an antibody produced in response to the hepatitis B surface antigen (HBsAg). What is the level of hepatitis B surface antibody levels that meets the immune requirements and treatments when exposed to the hepatitis B virus (HBV)? All will be in the following article.
What is hepatitis B antibody and how much does it meet?
What is the hepatitis B surface antigen (HBsAg)?
A positive result of an HBsAg test means that a person is infected with the hepatitis B virus, which can be acute or chronic. Infected people can spread the virus to others through their blood.
What are hepatitis B surface antibodies (HBsAb or anti-HBs)?
Hepatitis B surface antibody (HBsAb or anti-HBs) is an antibody produced in response to the hepatitis B surface antigen (HBsAg).
A positive test for HBsAb (or anti-HBs) indicates that a person has either successfully responded to the hepatitis B vaccine or has recovered from an acute hepatitis B infection. This result (along with a negative HbsAg result) means that you are immune to (protect against) hepatitis B in the future.
The results of HBV serological markers can be reported qualitatively or quantitatively in the form of international units (IU) or signals per threshold value (s / c)


Hepatitis B surface antigen (HBsAg) levels below 1 s / c are considered negative, while levels greater than 5 s / c are considered positive; or
Hepatitis B surface antibody concentration (Anti-HBs) ≥10 mIU / mL is considered standard, ie successful vaccination.


Hepatitis B Antibody, Treats When Exposed To The Hepatitis B Virus


What is the hepatitis B core antibody (HBcAb)?
HBcAb is an antibody that is part of the virus - it has no protective effect.
A positive HBcAb (or anti-HBc) test result shows past or present infection.
Interpretation of this test result depends on the results of the other two tests. Its presence with protective surface antibodies (HBsAb or anti-HBs positive) indicates previous infection and has recovered. For people with chronic infections, it often appears with the virus (HbsAg positive).
Check the level of hepatitis b antibody in the blood
Testing for hepatitis B antibodies
The hepatitis B surface antibody test is performed after vaccination to determine whether the vaccination has been successful.
Regular anti-HBs testing is not recommended
It is only recommended in certain groups:
People at risk of occupational exposure (especially medical and laboratory staff):
The antibody response to the hepatitis B vaccine varies widely between individuals.


Hepatitis B Antibody, Treats When Exposed To The Hepatitis B Virus

10-15% of adults do not respond or have poor response.
It is best to achieve anti-HBs levels> 100 mIU / mL;
However, generally accepted levels of ≥ 10 mIU / mL are sufficient to protect against infection;
Anti-HBs concentrations ≥ 100 mIU / mL do not need a main dose and repeat after 5 years;
People with anti-HBs concentrations of 10-100 mIU / mL should get one more dose at that time and repeat after 5 years;
An antibody concentration <10 mIU / mL is unresponsive to the vaccine. This will therefore be given as directed. People who still have anti-HBs concentrations <10 mIU / mL and have no signs of infection will require hepatitis B immunoglobulin (HBIG) for protection in case of exposure to the virus. People with chronic kidney disease need dialysis The effects of hepatitis B antibodies on patients with chronic kidney disease requiring dialysis are unclear. However, if the anti-HBs level is> 10 mIU / mL, there is still an immune response.
Antibody levels are monitored annually and if they fall below 10 mIU / mL, an booster dose of vaccine should be given to patients who have previously responded to the vaccine.
The booster dose should also be given to any hemodialysis patient who is planning to travel to high-risk countries if they have previously responded to the vaccine, especially if they Hemodialysis must not be repeated in the previous 12 months.


Hepatitis B Antibody, Treats When Exposed To The Hepatitis B Virus


Blood samples for hepatitis B surface antigen (or antibody) are tested
How to handle exposure to hepatitis B virus?
Hepatitis B immune globulin
HBIG provides passive immunity. It may provide immediate protection but is only temporary in case of exposure.
HBIG is given concurrently with the hepatitis B vaccine and does not affect immune activity. HBIG protects until the hepatitis B vaccine is effective.
It is recommended in high risk situations or for those who do not respond.
If an infection occurs at the time of vaccination, HBIG can still prevent the development of a carrier state.
The ideal time for injection is within 48 hours but no later than 7 days after exposure.
People with HbsAg or anti-HBs do not need to be injected.


Hepatitis B Antibody, Treats When Exposed To The Hepatitis B Virus

However, vaccines should not be delayed while waiting for the results of a blood test.
Post-exposure vaccinations are required in the following situations:
Babies born to mothers with chronic HBV disease or mothers with acute hepatitis B during pregnancy;
Having sex with people with hepatitis B;.

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