Muscle Relaxants And Precautions When Used

Tizanidine is a muscle relaxant used to treat symptoms of spasticity due to scattered sclerosis or spinal cord injury; Muscle cramps or jerks; Pain due to muscle contraction.
When taken orally, the drug will affect the central nervous system in the spinal cord and on the spinal cord, reducing muscle spasticity by increasing pre-synaptic inhibition of motor neurons at alpha-adrenergic receptors. The drug mainly acts on synaptic neurons. The result is a decrease in the stimulation of motor neurons on the spinal cord, which reduces muscle contraction but does not weaken excess muscle.
The drug has the maximum effect after taking 1

.5 hours and stops working after about 3-6 hours. Because the drug has a relatively short effect, it must be taken several times a day (3-4 times / day), depending on the needs of the patient. However, the dose should be adjusted according to the patient's response, do not exceed the dose for the desired therapeutic effect
The drug is well absorbed by oral administration.



Food does not affect the rate of absorption but affects the rate of absorption such as shortening the time to peak concentration of about 40 minutes and increasing peak plasma concentration by about 33%. When using the drug should be careful, because on the cardiovascular system and blood pressure drugs can cause bradycardia, hypotension.
The hypotensive effect depends on the dose and appears after a single dose of 2 mg or more. When a sudden change of position can increase the risk of orthostatic hypotension. In addition, the drug can cause liver damage (should be cautious for people with impaired liver function), cause drowsiness (caution for people who need alertness such as driving, operating machinery) or virtual. cupping on some people taking the drug. On the eyes, for experimental animals the drug causes retinal degeneration and corneal opaque However, there have been no reports of this effect in clinical studies.




In the elderly, use the drug only when careful consideration of benefits outweighs risk, because in the elderly, renal clearance may be reduced by 4 times. Experience in using drugs for children under 18 years of age is limited, so it is not recommended for children.
When using the drug, patients may experience undesirable effects such as: dry mouth, abdominal pain, diarrhea; myasthenia, back pain; drowsiness, drowsiness, fatigue, dizziness, depression ... To minimize the unwanted effects on the need to start with a low dose and then gradually increase to the effective dose that the user is still tolerated..

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