Note Undesirable Effects When Treating Osteoporosis

Alendronate is a drug that has a specific inhibitory effect on bone resorption. Preclinical studies show that, selective drug accumulation in active bone resorption sites, alendronate has the effect of inhibiting the activity of osteoclasts.
When treated with alendronate can significantly increase bone mass in the spine, femoral neck and transfer bone. In postmenopausal women 40 and older with osteoporosis (defined as having low bone mass, at least 2 standard deviations below the mean for pre-menopause), alendronate treatment significantly reduces the number of times Spinal fractures after 3 years of medication.
Bone mineral density increased significantly after 3 months of treatment with alendronate and continued throughout the course of medication

. However, after 1-2 years of treatment, if stopping alendronate therapy does not maintain the increase in bone mass.
The drug is used to treat and prevent osteoporosis in postmenopausal women, women at risk of osteoporosis or for those who wish to maintain bone mass and reduce the risk of later fractures. The drug is also used to prevent and treat osteoporosis caused by corticosteroids .



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Although in clinical studies, adverse drug reactions were generally mild and generally did not need to be discontinued. However, attention should be paid to undesirable effects on the gastrointestinal tract of the drug.
There have been reports of esophageal events such as esophagitis, esophageal ulcers, esophageal erosions, sometimes accompanied by bleeding in patients treated with this drug. In some cases, these events are severe and require hospitalization. Therefore, in the course of taking this drug if you see symptoms of difficulty swallowing, painful swollen pain or sternum .



., the patient must stop the medication and see a physician immediately for timely treatment.
The risk of serious esophageal events is greater among patients who lie down immediately after taking the medicine and / or do not swallow the tablet with a full glass of water and / or continue to take this medication after seeing symptoms. of esophageal irritation.
The drug can irritate the upper gastrointestinal mucosa and make it worse. Be careful when using the drug in patients with active gastrointestinal diseases such as esophageal diseases, gastritis, duodenitis or ulcers ...




To easily absorb the drug must be taken with plenty of water (about 200ml), do not use mineral water to drink. Take at least 30 minutes before eating, drinking or taking other medications. Even when taking the tablet with orange juice or coffee, the absorption of the drug has decreased markedly. Do not suck or chew the tablets when taken and avoid lying down for at least 30 minutes after taking the medicine so it can easily enter the stomach and reduce the potential for irritation of the esophagus.
Do not take the medication at bedtime or before waking up during the day. Calcium and vitamin D should be supplemented if the daily intake in the diet is insufficient..

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