Some Medicines Cause … Hepatitis

Almost every drug is metabolized in the liver, so if there is a problem with the liver, it will inevitably be affected by the medicine. Some drugs also have serious and typical levels of hepatitis ...
The liver is easily affected
The liver is a special detox and antitoxic organ of the body

. The anti-toxic effect of the liver manifests itself in the way that it decomposes drugs and toxins into non-toxic substances and eliminates them from the body.
Due to the peculiarity of the "door", the liver is most susceptible to attacks and inflammation due to drug toxicity. Although the rate of drug-induced hepatotoxicity is not much, it has serious consequences
According to statistical observations, the incidence of drug-induced liver disease is about 1.



4% and only 20% of these patients can survive The remainder were heavily poisoned and died. Different drugs have different hepatotoxicity and different rates of liver disease.
The hepatotoxic rate of the drug depends on their toxicity and the frequency of use. The greater the toxicity, the more often it is used, the more drug-induced liver disease.
Medications that cause hepatitis
Analgesics, antipyretics, non-steroidal anti-inflammatory drugs
Representatives of this group are acetaminophen, diclofenac, ibuprofen, naproxen, nimesulide, piroxicam, sulindac. These drugs have different chemical structures but have the same effect: antipyretic, anti-inflammatory and analgesic.
However, apart from the main effect, its side effects are also extremely ominous.



One of the side effects of this group is causing jaundice hepatitis, especially in infants. Especially when we use a medicine called acetaminophen with a common drug name is paracetmol.
Paracetamol is an over-the-counter antipyretic. If one or two antipyretic doses are used, it does not matter but high and prolonged use of the drug will cause hepatitis, especially in children. The incidence of liver disease ranges from 30-40%, a small percentage in drug-induced hepatitis.
The problem of jaundice hepatitis is posed when the duration of the use of the drug is over one week. Starting at this time, signs of jaundice hepatitis begin to appear. And if we do not pay attention, after only a short time more, the disease will go into typical phase.




Anti-thyroid drugs
Thiouracil is a typical drug of this group. The drug inhibits the absorption of iodine into the thyroid, so it reduces the synthesis of thyroxin hormone, used to treat cases of thyrotoxicosis such as Basedow's disease.
However, the drug also causes hepatitis. Right in the first week of use liver enzymes began to rise. If the drug users suffer from severe thyroid disease, they will be prescribed high doses, sometimes up to 8 tablets a day. Such high doses do not need a week, but only about three days can lead to liver complications.
On the other hand, the drug has to be used for a long time to complete the treatment so the risk of causing hepatitis is very large. Therefore, in the strategy of drug use as well as adherence to treatment, both physicians and patients must be wary of this group of drugs.



Its incidence of hepatitis is 10%.
TB medicine
There are many types of TB medicines and the typical TB treatment regimen is usually a combination of 4 drugs in an attack.
Among tuberculosis drugs, isoniazid, pyrazinamide, rifampicin are the most serious drugs, especially isoniazid. The liver's harmful effects are as dangerous as the synthetic anti-thyroid drug.
Right at the beginning of the drug, the drug caused liver enzymes to increase (like real hepatitis). Although it does not cause immediate jaundice, it can damage the entire liver of the patient.
Like the drug Basedow, TB medicines also have to be used continuously for a long time. Therefore the harm on the liver seems to be added up exponentially.



Without adequate protection, it is likely that we will have to turn to curing liver disease after curing tuberculosis.
Medications for epilepsy
So far there are about 20 anti-epileptic drugs including the old and new generations. Each antiepileptic drug has a different mechanism of action, but it is generally effective in increasing inhibition on the neurons surrounding the epilepsy.
And so the drug has the effect of preventing and restraining flares, reducing the spread of the seizures and controlling seizures. Unfortunately, whether new or old, they are chemical compounds that can alter the integrity of the liver. Valproat and phenytoin cause liver damage relatively well.
The degree of liver damage depends on the concentration used and depends on the patient's liver condition. If during the time of medication, the patient's liver has a problem, it is said that we have to treat two diseases simultaneously with epilepsy and hepatitis.



The incidence of epilepsy-induced liver disease is 7%.
Anti-cancer medicine
There are so many anticancer drugs that they are often called anti-cancer chemicals. These drugs are extremely poisonous and the hepatitis drug is not to be discussed. Anticancer drugs are considered to be toxic, extremely toxic to the secretion organs.
The liver may be microscopic.

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