To Be Safe When Taking Papaverin Pain Relievers
Today, the prescription of papaverin analgesic is different from before. If you do not know this information, the use will not be effective and may cause a catastrophe.
Papaverin is an active ingredient extracted from opium poppy, but only has analgesic effect due to spasms but not analgesic effect by inhibiting central nervous system like other opioid active substances (morphine, codeine).
The mechanism of papaverin's antispasmodic is phosphorylation and inhibits muscle contraction. Papaverin is classified as an anti-spasmodic analgesic analgesic, used to relieve pain due to increased gastrointestinal motility (gastroenteritis, gastroenteritis, enterocolitis) due to uterine spasms (in the system)
Papaverin also works against brain vasoconstriction, relaxes the heart muscle.
Previously, the drug has been used in cerebral ischemia, ischemic heart attack, bronchospasm due to asthma, angina pectoris.
However, it did not bring certain effects. Now there are many alternatives to treat these diseases that are better, less toxic, so they are not used for this anymore.
There is not enough information about the harm of papaverin to pregnancy, and the reproductive process. Previously, the drug was used against "threatening to miscarry," now there are many better, safer drugs, so it is rarely used.
Contraindications to papaverin analgesic for pregnant women
The latest literature (Vietnam Pharmacopoeia 2002) states "Do not use papaverin for pregnant women". There are no complete information on the excretion of papaverin into milk
Papaverin may cause hypersensitivity phenomena. Hypersensitivity in the liver manifests jaundice, digestive disorders, eosinophilia, changes in liver enzymes. Not recommended for people with a history of hypersensitivity to this drug. Immediately stop the drug when there is a phenomenon of liver hypersensitivity.
Papaverin intravenous drug when injected quickly can cause arrhythmia, apnea, death. Extreme caution should be used when taking this form of medication. Do not mix papaverin injection into ringer lactate infusion because it causes precipitation, degeneration of the drug, leading to catastrophe.
Papaverin can also cause atrial-ventricular conduction loss, transient ventricular premature beats, premature beats, or paroxysmal tachycardia, should not be used in complete atrioventricular block, and extreme caution should be taken Atrioventricular conduction loss.
Do not use for people with Parkinson's disease, especially when taking Levodopa medication because it will cause adverse interactions.
Papaverin vasoconstrictor, hypertension, should not be used for people with cranial hypertension, glaucoma. Prolonged use of high doses and (or) may cause dizziness, headache, drowsiness, lethargy, and habituation.
When taking papaverin appears effective very quickly, sustained for about 6 hours, so should be taken every 6 hours.
If the oral form of the active ingredient is released slowly, the effect appears later but is maintained for 12 hours, so the effective dose should be taken every 12 hours.. . Dịch vụ: Thiết kế website, quảng cáo google, đăng ký website bộ công thương uy tín
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