When To Use Loperamide?

One of the typical manifestations of food poisoning is diarrhea. This is characterized by signs such as bowel movements, and the number of bowel movements increases.
If this condition is prolonged, it will cause electrolyte disturbance, dehydration, even death. So at what stage of the disease does diarrhea medicine be used for food poisoning?
Loperamide - An antidiarrheal drug
Loperamide, a typical drug with clinically effective diarrhea. This is a synthetic derivative of piperidine, the opioid agonist in the intestinal nervous system

.
With this mechanism, loperamide is a drug that inhibits the longitudinal muscle of the intestinal wall, thus reducing peristalsis. So that the patient reduces the frequency of bowel movements, reducing the amount of water in the stool.
At the same time, the drug has the effect of increasing the tone of the sphincter, sphincter, which prevents the process of pushing the food out
Therapeutic efficacy is achieved at the usual dose.



With only the first dose of treatment, the patient has less bowel movements, his stomach is no longer stimulated, somewhat controlling his diarrhea without falling into an unbearable state.
With its central action causing the bowel spasm reaction to cause diarrhea, the drug is thought to work well with any disease.
Attention when using
The aforementioned advantages are difficult to cover the disadvantages of the drug, especially when using drugs when suffering from digestive disorders, food poisoning that has been treated many times, used in overdose, used too close together.
The most ominous disadvantage is abdominal distention. Abdominal distention is caused by decreased bowel movements, slow food circulation.
When excessive, abdominal distention may increase, causing bowel obstruction due to paralysis. Although this harm is rare, care should be taken for children and the elderly
Because side effects cause dizziness and fatigue, it should be considered for those with vestibular disorders.



People who have one of the organs of the vestibular system will get aggravated by this drug.
Because the drug is metabolized by the liver, it is not suitable for people with liver failure. The drug will aggravate the medical condition, will increase the manifestations of liver failure and also increase the side effects of the drug. In severe cases of cirrhosis, cirrhosis cases should not be used.
In addition, the drug can cause skin allergies, irritation, dry mouth. Some may have stomach upset or medication-induced stomach pain. It is rare to see drugs acting on nerves, a characteristic of opioid-based drugs.
Reports of neurotoxicity are mentioned but it is high dose in experimental animals and the mechanism has not been clarified.




In children, the drug has certain harmful effects that need attention. There have been reports of drug-induced gastrointestinal necrosis of loperamide in children.
These subjects were paralyzed because of high doses. So this is the main obstacle to loperamide that makes it not suitable for use in children. It is not recommended to stop diarrhea in children under 1 year of age.
Although there is no clear evidence of the teratogenic effect of the drug on the fetus, what it has been well known is that it can reduce the weight of a newborn. Therefore, mothers should note and prescriptions for pregnant women should also be considered by doctors.
It is important to know that the loperamide used in the treatment of food poisoning is only a symptomatic treatment that does not eliminate the cause.



So loperamid should never be used alone and may be cured.
In case of using up to a maximum dose in a day but the diarrhea has not stopped, it is necessary to study the cause of the disease and the treatment regimen.
In particular, if there is a suspicion of signs of a foodborne infection such as bacillus dysentery, it is absolutely necessary to carefully consider the use of loperamide because the slowing down of intestinal activity may facilitate bacteria entry into the bloodstream. Loperamide in these situations is almost not indicated.
Interventions for the use of loperamide medications are both beneficial and harmful. If we use it too early, germs will accumulate. But if we use it too late, harm has happened.
So it is best used when the poisoning pathogens have been identified.



But this is not easy.
The clinical use of drugs is more important than based on the cause, warning signs of danger and disease progression. It will help prevent the complications that are considered the most important..

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