The Nobel Medicine Prize in 2021 was awarded to two American scientists who discovered the super small secrets behind the tactile of the human. The scientist David Julius, was awarded the Nobel Medicine this year Use Capsaicin - A spicy compound from peppers can cause a hot feeling - to determine a sensor in the nerve heads of the skin responding to heat. In the meantime, Ardem PatapouTian scientist uses sensitive cells With pressure to discover new sensors that respond to mechanical stimulus in the skin and internal organs. Their discovery "has allowed us to understand how hot, cold and cold and Mechanical force can activate neuropathic pulses that allow us to perceive and adapt to the world around. This knowledge is being used to develop treatments for a variety of diseases, including chronic pain diseases "- Nobel Commission said
. Because heads from the 90s, scientists have reviewed Connect the heat transfer molecular pathways and the pressure is detected on the skin with the felt nervous pulse. Julius and his colleagues have begun to create a library of millions of DNA sections that contain genes found in feeling nerve cells. By adding turns to the genes into cells Usually does not respond to Capsaicin, they finally discovered a single gene responsible for the burning sensation created by Capsaicin
The gene they detected for the ability to create a protein called TRPV1, this protein is enabled at a hot enough temperature so that the body is considered to be painful. Julius and Patapoutian are independent using essential oils Mint to detect another protein, TPRM8, is activated by cold temperatures, as well as some other proteins enabled at different temperature ranges. Based on this work, PatapouTian and his colleagues Has created a library of 72 genes that they suspect are encrypted designs to create receptors for mechanical pressure. By carefully disabling these genes in the cell, they discovered that one of these genes has created a cornering protein that produces a small electrode signal every time they are agitated. The receptor (or receptor) that they discovered are not only important for the feeling of mechanical forces but also used in different ways to maintain blood vessels, along with the role of scientists Export in adjusting the body's blood pressure. After that discovery, they found a second protein receptor very important in sensing the position and movement of the body, a feeling of being called feeling Cognitive sense. They named two receptors Piezo1 and Piezo2, according to the Greek words that meant pressure. These discovered not only helped explain the mechanism behind the feeling of feeling like temperature and pressure, but also opened A world of countless capabilities for new drugs that affect receptors - from painkillers to drugs can reduce blood pressure on blood vessels and organs.Joseph Erlanger and Herbert Gasser, two people received The Nobel Medicine Prize in 1944, who first discovered specialized nerve cells reacted to both painful and painful touches. Before that, the Nobel Prize for Medicine 2020 was 3 houses Learn Harvey J
Alter and Charles M. Rice and Michael Houghton, who have discovered hepatitis C virus. . Dịch vụ:
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