How Does Pfizer And Moderna Create A Breakthrough In The Vaccine Race?

In order to get successful as Vaccine Covid-19 Pfizer and Moderna today, MRNA researchers underwent countless failures, diabelling, and rejected for decades of the instant: 00/8: 15nam in the North In 2004, after many times "beaten to rebuild", Dr. Katalin Kariko creates a breakthrough and wants to submit a patent, after more than 20 years since she started studying RNA information (or mRNA) - Genetic materials have the function of delivery of information in human cells, transporting formula from human DNA to the cells that produce protein. However, to be able to submit a patent, Kariko needs to persuade one Officials in the intellectual property at the University of Pennsylvania, where she used to work as a researcher, according to Financial Times. Their meeting took place without smoothness. "He is not very enthusiastic, he constantly asks 'what does this study help?' I was very disappointed because he didn't see its good," Kariko remembered

.When was about to acknowledge Failure, she suddenly realized that the other officer was bald. "I said: 'MRNA will be very good for the development of hair'. Suddenly, he stood up and ask 'Really?' But it can help '
So you're enthusiastic. " At the end of the meeting, he agreed to let Kariko submit a patent. At that time, it was a rare victory for Dr. Kariko, who studied MrNA modified to pave the way for Vaccine Covid-19 to be pfizer / Biontech and Moderna grow at extremely fast speeds. Now, Kariko is praised as one of the scientists who have a public in helping the world to repel the pandemic. However, for decades, her research Most colleagues are rejected and viewed as a game. She even had a nickname of respect for MrNA. Katalin Kariko. Photo: EuroNews. Kariko's struggle to convince officials mentioned above is just one of the difficulties that she and some scientists have studied other MRNA once encountered for decades
Through them, vaccines based on MRNA technology today, including Vaccine Covid-19 of Moderna and Pfizer / Biontech, most likely to be developed. MRNA supporters believe that Vaccine Covid-19 is just beginning step. Now, when this technology has been proven, they say it can be deployed to treat countless illnesses, from cancer, cystic fibrosis to HIV and heart disabilities. Scientific concerns in 6 The previous decade of MRNA's existence for the first time two French scientists, Jacques Monod and François Jacob, in 1961, a decade after the scientific gender discovered DNA.Adn as a material containing di Transmitting, emitting the body to direct the body to produce the necessary proteins so that the body works well. This destruction leads to a new difficulty question. DNA is in the cell nucleus, but proteins are created in cytoplasm - a completely different cell compartment.Monod and Jacob think that there must be an intermediate molecule somehow transmitting information to "factory". Production of body proteins. They call it "Messenger", abbreviated as "M" in MRNA. Human disease series can be caused by DNA mutations, including darling blood disease, Parkinson and may be Alzheimer. If scientists can interrupt the process of bringing errors by bringing a repaired mRNA into the body, they can prevent related diseases. However, far from medical science Constantly developing, after the discovery of MRNA is a quiet distance that lasts more than 40 years. Kariko Doctor began working on mRNA molecules in the 1980s at the Szeged Biological Research Center in Hungary hometown. She finished funding to pursue his work and started looking for a new academic organization to apply for support. Drew Drew Weissman (left) was injected with Covid-19. Photo: Penn Medicine. In 1985, she left Hungary and got a job at Temple University in Pennsylvania, USA. Here, Kariko constantly stood in front of the exhausted verge, but never lose faith in potential The function of mRNA. Believe that someday, this genetic material can be turned into a healing therapy for humans: a drug or a type of vaccine. Kariko's laboratory at Pennsylvania University, where she moved in 1989, lied opposite the medical center. "We have to take their science to the patient. I just passed the window and said: 'We have to take technology there "". In 1997, Ms. Kariko began working with Dr. Drew Weissman, a colleague at the University of Pennsylvania, who was studying tail cells Gai - the type of cell plays an important role in the body's immune system. Weissman said: "We continue to talk and decide to try to add mRNA to the spikes. We were surprised by the results. "When inserting mRNA into the tailless tail cells, Mr. Weissman found them to cause immune response to inflammation, because the medium-made matter cells were introduced and strange Strengthen bad reactions. This is quite difficult to understand because of the human body

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